Berberis Formula is a blend of barberry, goldenseal and Oregon grape extracts that are traditionally used to help maintain gastrointestinal health. The main bioactive ingredient in these extracts is berberine. Recent research demonstrates that berberine inhibits attachment of non-beneficial bacteria to the gastric mucosa. Berberine also mediates the transport of ions and water across intestinal epithelial cells. It helps maintain the balance between electrolytes and water.* Berberine can increase the expression of the Na+; H+ exchanger and aquaporin, which help enhance the absorption of sodium and water, respectively. Berberine also promotes proper intestinal epithelial tight junction formation and the permeability of these cells to promote appropriate gastrointestinal barrier function.* During low contractile states, berberine stimulates the jejunum through the activation of muscarinic receptors, resulting in support for intestinal motility.* • Traditionally used as a bitter to aid digestion and to help relieve digestive disturbances* • Includes goldenseal root extract, barberry root and stem extract, barberry root bark, Oregon grape root extract, and Oregon grape root

Risk Information: If you are pregnant or breastfeeding, do not use. Consumption with alcohol, other medications and/or natural health products with sedative properties is not recommended. Discontinue use and consult your healthcare practitioner if the following symptoms occur: nausea, vomiting, drop in blood pressure and/or difficulty breathing. High dosages of berberine can depress respiration, stimulate intestinal smooth muscle and reduce bronchial constriction. Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.