"Born from 15+ years of leading vaginal microbiome research, VS-01™ is the first vaginal suppository formulated with three proprietary Lactobacillus crispatus strains, clinically studied to rapidly restore a healthy vaginal microbiome, sustain regulated vaginal pH and is safe for long-term use. VS-01™ delivers three live L. crispatus strains (LUCA103™, LUCA011™, LUCA009™) selected for their strong association with vaginal microbiome stability and resilience. These strains were isolated from clinical vaginal samples of healthy women with a stable, L. crispatus-dominant vaginal microbiome. VS-01™’s strains are combined with a rich complex of nutrients and an innovative prebiotic to create the ideal environment and energy source for the probiotic ecology to not only survive, but thrive. Engineered to maximize exposure to the vaginal wall, Seed’s SMART Tablet™ slow-release delivery technology is clinically studied as the most effective and superior delivery system, when compared to vaginal and oral formats. In VS-01™’s first randomized, double-blind, placebo-controlled clinical trial, VS-01™ rapidly converted 90% of participants to an optimal vaginal microbiome in 21 days, compared to both a leading oral probiotic for vaginal health and placebo. Additionally, 100% of VS-01™ participants maintained a regulated vaginal pH.1Evidence-based benefits of VS-01™ include: ∙ Rapidly restores a healthy vaginal microbiome ∙ Maintains a resilient vaginal microbiome ∙ Maintains optimal vaginal pH ∙ Is safe, tolerable, and non-disruptive Citation: Ravel, J., Simmons, S., Greenwood Jawa, E., Gottfried, S., Greene, M., Kellogg-Spadt, S., Gevers, D., Harper, D. IDSOG Annual Meeting 2024."