This formula is an optimal methylation formula with activating co-factor created by Kendal Stewart, MD to support the methylation pathway and provide adequate folinic acid and methyl folate (5-MTHF). This product is designed to be used in conjunction with the Methylation Complete Fast Dissolves OR Methylation Pro Topical that provides the activating B12 co-factors to deliver the additional tetrahydrofolate to support neurological and immune recovery. For those who have high folic acid levels in the blood plasma, then it can be assumed that folate is not being converted and entering the nervous sytem, immune system and blood brain barrier. Most often poor methylators will need additional folate.