Supports Emotional Well-Being*. Supports Joint Health*. Enteric Coated. SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support.* NOW® SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. Natural color variation may occur in this product.