Venous Support contains clinically-studied botanical and flavonoid combinations to support the connective tissue integrity of veins and capillaries. Optimal function of the venous circulatory system is essential for controlling fluid balance within the tissues of the upper and lower extremities, and to maintain normal volume of the leg and hemorrhoidal veins. Horse Chestnut Seed Extract contains escin, and Butcher's Broom contains ruscogenins; these saponins are responsible for effects on vascular tone and permeability. The flavonoids diosmin and hesperidin, often combined with vitamin C, also have important influences on vascular connective tissue.*